Bringing IPF Chronic Cough

into the Open Air

The Impact of Chronic Cough in IPF

Chronic Cough in idiopathic pulmonary fibrosis (IPF) is more than just a symptom of a life-threatening disease. It impacts patients’ quality of life (QoL) and may also contribute to enhancing activation of profibrotic mechanisms and disease worsening in IPF.1

Chronic cough has been experienced in up to


of IPF patients.2,3

Severe & Difficult

for healthcare professionals to treat.3

There are currently NO treatment options approved for the use of chronic cough in IPF.

Cough in IPF is frequently resistant to conventional antitussive therapies. 3

Median 24-hr cough counts for cough in IPF.4,5

4 Hallmark Characteristics of Cough in IPF

Severe and Difficult to Treat 3

Triggered Easily 6,7

Often Dry and Non-Productive 8

Patients’ QoL Impacted 1,4,7,9,10

Severe and difficult to treat” 3

 Triggered Easily 6,7

 Often Dry and Non-Productive 8

Patients’ QoL Impacted 1,4,7,9,10


1. Van Manen M.J., et al., Eur Respir Rev, 2016. doi: 10.1183/16000617.0090-2015

2. Ryerson CJ, et al., Respirology, 2011. doi: 10.1111/j.1440-1843.2011.01996.x

3. Hope-Gill BD, et al., Am J Respir Crit Care Med, 2003. doi: 10.1164/rccm.200304-597OC

4. Key AL, et al., Cough, 2010. doi: 10.1186/1745-9974-6-4

5. Van Manen M, Birring S, Vancheri C, et al. Cough measurements in patients with idiopathic pulmonary fibrosis (IPF). Am J Respir Crit Care Med 2015; 191: A4422

6. Harrison NK., Cough 2013. doi: 10.1186/1745-9974-9-9

7. Voice of the Patient Report: “Idiopathic Pulmonary Fibrosis”, March 2015

8. Swigris JJ, et al., Health Qual Life Outcomes, 2005. doi: 10.1186/1477-7525-3-61

9. Wakwaya Y, et al., Chest, 2021. doi: 10.1016/j.chest.2021.05.071

10. Bradaia F, et al., Incontinence urinaire a la toux au cours des pneumopathies interstitielles diffuses [Urinary incontinence due to chronic cough in interstitial lung disease]. Rev Mal Respir, 2009; 26: 499–504. 

Trevi Therapeutics New Haven, CT.

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