Chronic Cough Goes Beyond What You Hear

Chronic cough may impact the daily lives of patients with idiopathic pulmonary fibrosis (IPF) and non-IPF interstitial lung diseases (non-IPF ILDs)

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Real Lives, Real Impact

Patients living with idiopathic pulmonary fibrosis (IPF) and non-IPF ILDs often experience chronic cough, a cough lasting at least 8 weeks.1-3 For many, the burden extends beyond the act of coughing alone and impacts them physically, emotionally, and socially.

“Cough has taken a part of my life away. Part of my dignity. My self-respect.”

-Steve
Patient living with IPF-related chronic cough

“A treatment for my chronic cough would give me so much peace back.”

-Theresa
Patient living with Sjögren's autoimmune ILD-related chronic cough

“It has completely robbed me of my life.”

-Renée
Patient living with pulmonary fibrosis-related chronic cough

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Learn how chronic cough impacts Daily life

Many patients with IPF and non-IPF ILDs experience chronic cough

~140k

U.S. patients with IPF4-6

60-70%

have uncontrolled chronic cough7

~228k

U.S. patients with non-IPF ILDS8

50-60%

have uncontrolled chronic cough3,9

Onset of IPF typically occurs in the seventh decade of life.10

Chronic cough is often persistent and severe

A survey conducted with the U.S. Pulmonary Fibrosis Foundation’s (PFF) Community Registry, resulted in insights from 197 patients self-reporting IPF or non-IPF ILDs and experiencing chronic cough (greater than 8 weeks).11

%

reported coughing episodes lasting more than 30 seconds

%

reported chronic cough for over 2 years

%

reported their cough severity as moderate to severe

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IPF and non-IPF ILD-related chronic cough: A burden with no FDA-approved treatments

Patients with IPF and non-IPF ILDs describe chronic cough as unpredictable, difficult to control, and often unresponsive to commonly used approaches.

There are no FDA-approved treatments and current antifibrotics have not demonstrated a benefit in cough reduction.12-13

Learn about clinical trials researching potential new treatments

%

reported having no relief or only partial/somewhat relief with treatments that they are currently using or have tried in the past for their chronic cough11

“I have tried 15 different medications, not including over the counter products or cough suppressants, and nothing has worked for me.”

-Renée
Patient living with pulmonary fibrosis-related chronic cough

References

  1. Morice AH et al. Eur Respir J. 2020 doi: 10.1183/13993003.01136-2019
  2. Interviews and quantitative study conducted by Indegene for Trevi, June 2022 with US pulmonologists (n = 100)
  3. Based on Pulmonologists who managed Non-IPF PF-ILD patients with chronic cough in the last 12 months, June 2022 (N=30)
  4. Raghu G et al. ERJ. 2016 doi: 10.1183/13993003.01653-2015
  5. Raghu G et al. Lancet Respir Med. 2014 doi: 10.1016/S2213-2600(14)70101-8
  6. U.S. Census NC-EST2023-AGESEX-RES
  7. Ryerson CJ et al. Resp 2011. doi: 10.1111/j.1440-1843.2011.01996.x
  8. Trevi Internal Analysis
  9. Trushenko NV et al. Diagnostics. 2025 doi: 10.3390/diagnostics15091139.
  10. Herberts MB et al. BMC Pulm Med. 2023 doi: 10.1186/s12890-023-02565-7.
  11. Kulkarni et al., poster presentation at PFF Summit (2025)
  12. vanManen M et al. ERJ. 2017 doi: 10.1183/13993003.01157-2017
  13. vanManen M et al. ERJ. 2016 doi: 10.1183/13993003.congress-2016.PA785