No Clear Path to Control
There are no approved treatments for chronic cough in the United States.
Current off-label therapies offer only limited relief, leaving many patients in a difficult cycle of trying different medications with little success.1 For patients with chronic cough in IPF and non-IPF ILD, relief from their cough can feel out of reach. Ongoing clinical research shows promise, offering patients hope for an effective treatment option.2
Clinical Research Offers Hope
Research into new treatments for chronic cough in IPF and non-IPF ILD is advancing, offering hope to those living with this challenging condition.
Interested in Volunteering for a Clinical Trial?
WHAT IS A CLINICAL TRIAL?
A clinical trial is medical research to learn more about how a potential new medication, or an existing medication works. The research helps to answer important questions on its effectiveness and its safety.
All medications must be tested in research studies before patients can receive the medication from their doctor. Strict rules and regulations ensure that clinical research studies are closely watched and that all study participants are treated ethically and fairly.
WHY IS IT IMPORTANT TO PARTICIPATE IN CLINICAL TRIALS?
Clinical trials can only take place when patients choose to participate.
Examples of reasons patients choose to join clinical trials include:
- To understand more about their disease
- To potentially gain access to new medical treatments before they are available to the wider public
- To help find new or better treatments and therapies
WHO CONDUCTS CLINICAL TRIALS?
Clinical trials are run by a research team that may include doctors, nurses, and other healthcare professionals. Most are paid for by a sponsor that is a pharmaceutical company.
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Chronic Cough in Their Own Words
“I call myself the cough medicine queen because if I add up everything that I have tried to control this cough. It’s been 15 different medications.”
— Renée, US Patient with Idiopathic Pulmonary Fibrosis
*This quote is from a patient who was compensated for their participation in a patient advisory board.
References
- Trushenko, N. V., Suvorova, O. A., Schmidt, A. E., Chikina, S. Y., Levina, I. A., Lavginova, B. B., & Avdeev, S. N. (2025). Updates on the Prevalence, Quality of Life, and Management of Chronic Cough in Interstitial Lung Diseases. Diagnostics (Basel, Switzerland), 15(9), 1139. https://doi.org/10.3390/diagnostics15091139
- Tang, B. M., Craig, J. C., Eslick, G. D., Seppelt, I., & McLean, A. S. (2009). Use of corticosteroids in acute lung injury and acute respiratory distress syndrome: a systematic review and meta-analysis. Critical care medicine, 37(5), 1594–1603. https://doi.org/10.1097/CCM.0b013e31819fb507
Trevi Therapeutics New Haven, CT.
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