An Unmet Need for Chronic Cough in IPF

Cough in IPF is often severe and difficult for practitioners to treat and there is a lack of available therapies. 1

Current Off-Label Treatments

Practitioners have tested an array of treatments to help combat cough in IPF.

Neuromodulators

No clinical trials have been conducted in IPF Chronic Cough specifically.2

Low dose steroids

While often tested, there is not substantial data to support if low dose steroids work.1

Antitussive therapy

Usually has no impact on IPF cough.1

Speech therapy

No clinical trials have been conducted in IPF Chronic Cough specifically.2

Neuromodulators

No clinical trials have been conducted in IPF Chronic Cough specifically.2

Antitussive therapy

Usually has no impact on IPF cough.1

Low dose steroids

While often tested, there is not substantial data to support if low dose steroids work.1

Speech therapy

No clinical trials have been conducted in IPF Chronic Cough specifically.2

While searching for relief from chronic cough, the trial and error of testing different therapies can lead patients and clinicians to feel frustrated.1

There are currently no approved therapies for IPF patients suffering from chronic cough.

Looking for helpful tips for managing your patients’ cough? Action for Pulmonary Fibrosis has put together this list here.

Clinical Research

Research is currently being conducted on possible therapies for chronic cough in IPF. Your patients can join a clinical trial of an investigational therapy by accessing them through clinicaltrials.gov

References

1. Hope-Gill BD, et al., Am J Respir Crit Care Med, 2003. doi: 10.1164/rccm.200304-597OC

2. Wakwaya Y, et al., Chest, 2021. doi: 10.1016/j.chest.2021.05.071

Trevi Therapeutics New Haven, CT. 

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