Research

The following research explores the multidimensional burden of chronic cough in patients with idiopathic pulmonary fibrosis (IPF) and non-IPF interstitial lung diseases (non-IPF ILDs). These findings highlight the physical, emotional, and social impact of chronic cough on these patients and the remaining unmet need in clinical practice.

An anonymous online survey was conducted with participants from the U.S. Pulmonary Fibrosis Foundation (PFF) Community Registry in June-July 2025. Eligible participants were adults who self-reported a diagnosis of IPF or non-IPF ILD and chronic cough (cough for at least 8 weeks). A total of 197 patients met eligibility criteria and completed the survey.
The survey study was sponsored by Trevi Therapeutics, Inc. in partnership with the Pulmonary Fibrosis Foundation (PFF) Community Registry.

Poster 1 - Kulkarni et al., PFF Summit 2025

Chronic cough is common in patients with IPF and non-IPF ILDs, yet its burden is frequently under characterized in clinical practice. This research sought to quantify the patient-reported impact of chronic cough across physical, emotional, and social domains.

Key Findings:

  • 78% reported episodes lasting more than 30 seconds
  • 76% reported chronic cough for over 2 years
  • 68% rated cough severity as moderate to severe
  • 63% reported no or only partial relief from treatments
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Poster 2 - Swigris et al., ATS 2026

Building on earlier survey data, this poster sought to provide a more detailed characterization of the multidimensional burden of chronic cough from the patient perspective — with a particular focus on emotional well-being, social functioning, and relationship impact. The research also examined treatment experience and cough severity over time.

Key Findings:

  • 96% reported worrying about their cough
  • 76% felt cough interfered with routine activities
  • 75% felt cough contributed to feelings of depression, sadness, or low mood at some point
  • 67% reported avoiding social situations because of their cough
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Research is intended for educational and informational purposes.